LYSOSOMAL ENZYMES IN CELLS INFECTED WITH CYTOPATHIC AND NON-CYTOPATHIC VIRUSES
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چکیده
منابع مشابه
Lysosomal Enzymes in Cells Infected with Cytopathic and Non-cytopathic Viruses
In chick embryo cells infected with fowl plague virus, an avian strain of influenza A which produces cytopathic effects, lysosomal enzymes were released from the particulate to the supernatant fraction of homogenates within 6 hours of infection. This change occurred in the presence of high concentrations of parafluorophenylalanine, suggesting that the changes were due to redistribution of prefo...
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One type of cell-virus interaction leads to more or less severe cytopathic effects, which may take various forms (1). However, such cytopathic effects are not always observed when virus multiplication occurs, e.g. with influenza A in human embryo lung cultures (2). Cases are also known in which severe cytopathic effects take place but there is no multiplication of virus, e.g. vaccinia in macrop...
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Activities of the enzymes beta-glucuronidase, acid phosphatase, acid DNAase, acid RNAase, and acid protease have been measured in the lysosomal and supernatant fractions of mouse liver cells and monkey kidney cells before and after infection with mouse hepatitis virus and vaccinia virus, respectively. In the infected cells there was easily measurable release of lysosomal enzymes into the supern...
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Lactic dehydrogenase and beta-glucuronidase were assayed in tissue culture fluids and cellular lysates, respectively, from BHK-21/13S and Iota cell cultures infected with rabies virus. Activation of lysosomal enzymes was shown from the day 4 of infection on, without any indication of cytopathic effect.
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It has already been reported by several investigators that characteristic morphological features are seen in HeLa cells infected with adenoviruses either by means of electron microscopic studies or by light microscopy of stained preparation's (Harf ord, Hamlin, Parker and van Ravenswaay, 1956; Morgan, Howe, Rose and Moore, 1956; Kj ellen, Lagermalm, Svedmyr and Thorsson, 1955; Boye.r, Leuchtenb...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1965
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.121.3.477